Mixed lymphocyte-platelet, lymphocyte-kidney cell and lymphocyte-liver cell reactions in rats.

NISHIHIRA, T. and FUJII, G. Mixed Lymphocyte-Platelet Lymphocyte-Kidney Cell and Lymphocyte-Liver Cell Reactions in Rats. Tohoku J. exp. Med., 1972, 108 (1), 1-7 The lymphocyte-platelet reaction (MLPR) in various donor recipient combinations in rats showed a nearly coincident relationship with the mixed lymphocyte culture reaction (MLC). The kidney cells had not enough stimulating effect against allogeneic lymphocytes to induce blastoid transformation. The liver cells stimulated allogeneic lymphocytes to induce blastoid transforma tion and to increase incorporation of 3H-thymidine, and the magnitude of the mixed lymphocyte-liver cell culture reaction in various donor recipient combina tions corresponded to MLC and survival time of skin allografts. cultures of lymphocytes mixed with kidney cells, liver cells or platelets; organ specific antigens; transplantation immunity